Deion Sanders , the Pro Football Hall of Famer and head coach of the Colorado Buffaloes , revealed he is facing new health challenges following Colorado ’s 35-21 loss to TCU on Saturday. The 58-year-old coach described intense pain in his leg and raised concerns about potential blood clots . Despite these struggles, Sanders remains committed to leading his team while navigating a challenging recovery journey.
Deion Sanders on blood clots and ongoing pain
“Cat’s out of the bag, all right. I think I’ve got more blood clots,” Sanders told the media. “It don’t make sense. I’m hurting like crazy. I’m not getting blood to my leg. That’s why my leg is throbbing.” During the game, Sanders was seen sitting at times due to the discomfort. He has a doctor’s appointment scheduled for Monday to address the issue.
Sanders has faced similar complications before. In 2021, he underwent the amputation of two toes on his left foot due to blood clot issues while coaching at Jackson State. He also missed the Pac-12 media day in 2023, his first year at Colorado, after procedures on his right leg and left foot to remove clots and straighten toes. These ongoing medical concerns have become part of his life as he continues to coach at a high level.
Overcoming cancer and staying motivated
Sanders’ health battles extend beyond blood clots. Earlier this year, he underwent treatment for bladder cancer, including the reconstruction of a portion of his intestine to function as a bladder. His doctor confirmed that he is cured from the cancer, but the recovery process has been physically demanding.
“When we hear that word, it’s usually a life sentence attached to it. But not this time. Not this time, because God got me,” Sanders shared. Reflecting on his journey, he said, “Slowly but surely, I built myself back up. I’m able, I’m strong. It has been a tremendous journey, and I’m truly thankful that God is so good.”
Even amidst his pain, Sanders uses his experience to inspire others. On Good Morning America, he shared, “I choose to rise up and not to stay down. I want everybody to understand you can make it. We’ve all got something to fight. It may not be cancer, but it’s something. But you will overcome. We can do this.”
Despite Colorado’s 2-4 record and a 0-3 start in the Big 12, Sanders’ determination and resilience remain clear. His story is a reminder that strength comes not from avoiding adversity, but from facing it head-on with courage and hope.
Also Read: Former NFL QB Mark Sanchez released from hospital, heading to jail after shocking truck driver stabbing incident
Deion Sanders on blood clots and ongoing pain
“Cat’s out of the bag, all right. I think I’ve got more blood clots,” Sanders told the media. “It don’t make sense. I’m hurting like crazy. I’m not getting blood to my leg. That’s why my leg is throbbing.” During the game, Sanders was seen sitting at times due to the discomfort. He has a doctor’s appointment scheduled for Monday to address the issue.
Deion Sanders was seen wearing one shoe during their game against TCU
— Bleacher Report (@BleacherReport) October 5, 2025
He opened up after saying he's dealing with more blood clots and that's why his leg is throbbing
(via @DNVR_Buffs) pic.twitter.com/dYu4w3HrbD
Sanders has faced similar complications before. In 2021, he underwent the amputation of two toes on his left foot due to blood clot issues while coaching at Jackson State. He also missed the Pac-12 media day in 2023, his first year at Colorado, after procedures on his right leg and left foot to remove clots and straighten toes. These ongoing medical concerns have become part of his life as he continues to coach at a high level.
Overcoming cancer and staying motivated
Sanders’ health battles extend beyond blood clots. Earlier this year, he underwent treatment for bladder cancer, including the reconstruction of a portion of his intestine to function as a bladder. His doctor confirmed that he is cured from the cancer, but the recovery process has been physically demanding.
“When we hear that word, it’s usually a life sentence attached to it. But not this time. Not this time, because God got me,” Sanders shared. Reflecting on his journey, he said, “Slowly but surely, I built myself back up. I’m able, I’m strong. It has been a tremendous journey, and I’m truly thankful that God is so good.”
Even amidst his pain, Sanders uses his experience to inspire others. On Good Morning America, he shared, “I choose to rise up and not to stay down. I want everybody to understand you can make it. We’ve all got something to fight. It may not be cancer, but it’s something. But you will overcome. We can do this.”
Despite Colorado’s 2-4 record and a 0-3 start in the Big 12, Sanders’ determination and resilience remain clear. His story is a reminder that strength comes not from avoiding adversity, but from facing it head-on with courage and hope.
Also Read: Former NFL QB Mark Sanchez released from hospital, heading to jail after shocking truck driver stabbing incident
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